A Precision Medicine Approach to Improve the Prevention, Diagnosis, and Treatment of Depression

Portal ID:
Opportunity Type:
  • Grant
Last Updated:



The California Initiative to Advance Precision Medicine (CIAPM) will award up to $9 million total across three to five independent research teams ($1.8 to $3 million per team) over a three-year project term to further understanding about the prevention, diagnosis, and treatment of depression.


The principles of precision medicine call for the modern application of scientific data and clinical practice toward the individualization of prevention, diagnosis, measurement, and treatment of disease and wellbeing. This funding opportunity aims to drive innovation in applying a precision medicine approach to improve clinical outcomes for patients with depression, particularly as a path to reduce health inequities. To ensure the RFP is responsive to community needs, CIAPM hosted a Request for Information and held listening sessions throughout California.

California-based research teams must be co-led by at least one non-profit academic research institution and at least one non-profit community-based organization, patient advocacy group, community clinic, or public or tribal entity that provides support to people with or at risk for depression. A key component of these projects is authentic community partnerships with patients and other stakeholders who have a connection to, expertise in, or lived experience related to depression from project conception to project completion and beyond. By the full proposal stage, projects must also include at least one private sector collaborator who contributes in-kind, financial, or other resources to the project. The private sector collaborator should not be a PI and CIAPM funds may not be allocated to support salaries of private sector collaborators.

Letters of Intent (LOI) are required, nonbinding, and not scored during the selection process, but must be received by the noted deadline. CIAPM encourages applicants to begin drafting the concept proposals as soon as possible and not necessarily wait until after LOI submission.

Key Dates

Release of the Notice of Funding Intent | 01/31/2023

Request for Information & Listening Sessions | July-August 2023

Announcement of the RFP | 09/22/2023

Due: Letters of Intent to Submit a Proposal | 10/30/2023 by 12:00 p.m. (Noon)

Due: Concept Proposals | 12/1/2023 by 12:00 p.m. (Noon)

Notification of Finalists | January 2024

Due: Full Proposals (for Finalists only) | 02/15/2024 by 12:00 p.m. (Noon)

Awardees Announced | March 2024

Anticipated Project Start | June 2024

Duration of Projects | 36 months

All times listed are in Pacific Time.

Eligibility Requirements

Eligible Applicants:

  • Nonprofit
  • Public Agency
  • Tribal Government

Research teams are to be co-led by community representatives and researchers. The Lead Principal Investigator (PI) must be affiliated with a non-profit academic research institution based in California. At least one additional PI must be affiliated with a California-based nonprofit community-based organization, patient group (e.g. advocacy organization), community clinic, or public or tribal entity that provides support to people with depression.

Important Dates

The date (and time, where applicable) by which all applications must be submitted to the grantmaker. Time listed as “00:00” equates to midnight.
The date on which the grantor expects to announce the recipient(s) of the grant.
Q2 2024
The length of time during which the grant money must be utilized.
3 years

Funding Details

The total projected dollar amount of the grant.
A single grant opportunity may represent one or many awards. Some grantors may know in advance the exact number of awards to be given. Others may indicate a range. Some may wish to and wait until the application period closes before determining how many awards to offer; in this case, a value of “Dependent” will display.
3 – 5
Grant opportunities representing multiple awards may offer awards in the same amount or in varied amounts. Some may wish to wait until the application period closes before determining per-award amounts; in this case, a value of “Dependent” will display.
$1,800,000 – $3,000,000
Certain grants require that the recipient(s) provide a letter of intent.
Yes ( see Description for details )
Certain grants require that the recipient(s) be able to fully or partially match the grant award amount with another funding source.
The funding source allocated to fund the grant. It may be either State or Federal (or a combination of both), and be tied to a specific piece of legislation, a proposition, or a bond number.
  • State
The manner in which the grant funding will be delivered to the awardee. Funding methods include reimbursements (where the recipient spends out-of-pocket and is reimbursed by the grantor) and advances (where the recipient spends received grant funds directly).
  • Reimbursement(s)

How to Apply

State agencies/departments recommend you read the full grant guidelines before applying.


For questions about this grant, contact:
David Reiner, 1-916-323-9164, ciapm@opr.ca.gov